Description
Springer In Vivo Models Of Hiv Disease And Control by Herman Friedman , Steven Specter
An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV.Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies. Ventral and Dorsal Contributions to Hematopoiesis in Xenopus.- Genetic Dissection of Hematopoiesis Using the Zebrafish.- Extra- and Intraembryonic HSC Commitment in the Avian Model.- Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation.- Yolk Sac Development in Mice.- Long-Term Reconstituting Hematopoietic Stem Cell Capacity in the Embryo.- The Endothelium: The Cradle of Definitive Hematopoiesis?.- Endothelial and Hematopoietic Cells in the Intraembryonic Compartment.- Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo.- Hematopoietic Development in Drosophila: A Parallel with Vertebrates.- Intraembryonic Development of Hematopoietic Stem Cells during Human Ontogeny: Expression Analysis.- Gene and Cell Therapy Involving Hematopoietic Stem Cell.