Description
Springer Etiology and Morphogenesis of Congenital Heart Disease From Gene Function and Cellular Interaction to Morphology 1st Editon 2018 Softbound by Toshio Nakanishi, Roger R. Markwald, H.Scott Baldwin, Bradley B. Keller, Deepak Srivastava, Hiroyuki Yamagishi
This volume focuses on the etiology and morphogenesis of congenitalheart diseases. It reviews in detail the early development and differentiation ofthe heart, and later morphologic events of the cardiovascular system, coveringa wide range of topics such as gene functions, growth factors, transcriptionfactors and cellular interactions that are implicated in cardiac morphogenesisand congenital heart disease. This book also presents recent advances in stemcell and cell sheet tissue engineering technologies which have the potential toprovide novel in vitro disease models and to generate regenerative paradigmsfor cardiac repair and regeneration. Thisis the ideal resource for physician scientists and investigators looking forupdates on recent investigations on the origins of congenital heart disease andpotential future therapies. PartI. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Nowand Future .- Reprogramming Approaches toCardiovascular Disease: From Developmental Biology to Regenerative Medicine.- The arterial epicardium, a developmental approach to cardiac diseaseand repair.- Cell sheet tissue engineering for heart failure.- Future treatment of heart failure and pathophysiological analysis ofvarious heart diseases using human iPS cell-derived cardiomyocytes.- Congenital heart disease: in search of remedial etiologies.- Part II. Left-Right Axis andHeterotaxy Syndrome.- Left-rightAsymmetry and Human Heterotaxy Syndrome.- Roles of motileand immotile cilia in left-right symmetry breaking.- Role of ciliaand left-right patterning in congenital heart disease.- Pulmonaryarterial hypertension in patients with heterotaxy /polysplenia syndrome.- Part III. Cardiomyocyte and MyocardialDevelopment.- Single Cell Expression Analyses ofEmbryonic Cardiac Progenitor Cells.- Meis1 Regulates Post-Natal CardiomyocyteCell Cycle Arrest.- Intercellular signalling in cardiac development anddisease: NOTCH.- The epicardium in ventricular septation during evolutionand development.- S1P-S1p2 signaling in cardiac precursor cells migration.- Myogenic progenitor cell differentiation is dependent on modulation ofmitochondrial biogenesis through autophagy.- The role of thethyroid in the developing heart.-Part IV. Valve Development and Diseases.- Atrioventricular valve abnormalities: From molecular mechanismsunderlying morphogenesis to clinical perspective.- MolecularMechanisms of Heart Valve Development and Disease.- A novel role forendocardium in perinatal valve development: Lessons learned from tissuespecific gene deletion of the Tie1 receptor tyrosine kinase.- The Role of the Epicardium in the Formation of the Cardiac Valves inthe Mouse.- TMEM100, a novel intracellular transmembrane proteinessential for vascular development and cardiac morphogenesis.- Cell autonomous regulation of BMP-2 in endocardial cushion cells duringAV valvuloseptal morphogenesis.-Part V. The Second Heart Field and Outflow Tract.- Properties of cardiac progenitor cells in the second heart field.- Nodal signaling and congenital heart defects.- UtilizingZebrafish to Understand Second Heart Field Development.- A history andinteraction of outflow progenitor cells implicated in “Takao syndrome”.- The loss of Foxc2 expression in the outflow tract links the interruptedarch in the conditional Foxc2 knockout mouse.- Environmentalmodification for phenotype of truncus arteriosus in Tbx1 hypomorphic mice.- Part VI. Vascular Development andDiseases.- Extracellular matrix remodeling invascular development and disease.- The “cardiac neural crest” conceptrevisited.- Roles of endothelial Hrt genes for vascular development.- Placental Expression of Type 1 and 3 Inositol Trisphosphate Receptorsis Required for the Extra-embryonic Vascular Development.- Tissue Remodeling in Vascular Wall in Kawasaki Disease-relatedVasculitis Model Mice.- PartVII. Ductus Arteriosus.- Progerinexpression during normal closure of the human ductus arteriosus: A case ofpremature ageing?.- The multiple roles of prostaglandin E2 in the regulation ofthe ductus arteriosus.- Developmental Differences in the Maturation of SarcoplasmicReticulum and Contractile Proteins in Large Blood Vessels Influences TheirContractility.- Fetal and Neonatal Ductus Arteriosus is Regulated withATP-sensitive Potassium Channel.-Part VIII. Conduction System and Arrhythmia.- Regulation of vertebrate conduction system development.- Cardiac Pacemaker Development from a Tertiary Heart Field.- Endothelin receptor type A expressing cell population in the inflowtract contributes to chamber formation.- Specific isolation of HCN4 positivecardiac pace-making cells derived from embryonic stem cell.- Part IX. Current M